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Her interest in hematologic malignancies and curiosity for epigenetics led her to join the Bernt lab, which was at that time located at the University of Colorado Denver. Simone moved with the lab from Denver to Philadelphia. She works on a protein called Meningioma-1 (MN1) that, when overexpressed, causes a highly aggressive AML (Acute Myeloid Leukemia). To investigate the mechanism of this mysterious and unique protein she uses a variety of methods such as mass spectrometry, chromatin conformation assays, immunoprecipitation methods, next-generation sequencing, and in vivo models. Outside of lab Simone enjoys discovering the US (especially the Rocky Mountains), hiking, and meeting friends. Click here for extensive publication list. Contact: riedels@chop.edu https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1614201754659-FZRSDUL5Q0BDES0Q6Y7X/SR+dogsledding.JPG Lab Members - Simone Riedel, PhD Research Scientist https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1614201795769-9P27DJKGQK8IZ49FX9U9/Postdoc+appreciation+week+%281%29.jpg Lab Members - Simone Riedel, PhD Research Scientist https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1614201809037-Y2M08QA3BVQV6YYMF0HP/Screen+Shot+2021-02-24+at+1.35.43+PM+%281%29.png Lab Members - Simone Riedel, PhD Research Scientist https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1614203788386-HUBPA8DPPG72E4WA9YZQ/Jessandme.jpg Lab Members - Simone Riedel, PhD Research Scientist https://www.theberntlab-chop.org/lab-members/gabe-bobrin monthly 0.5 2025-10-08 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/9229c076-e422-4136-b444-b5909d9528ff/Gabe+2025.jpg https://www.theberntlab-chop.org/lab-members/kathrin-bernt monthly 0.5 2025-10-08 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1614204703164-BQ8OE69ULZBC6TWV191H/Kathrin+Bernt Lab Members - Kathrin Bernt, M.D. Principal Investigator - Dr. Kathrin Bernt (she/her) Dr. Bernt is a physician scientist dedicated to understanding how hematopoietic development is falsely re-wired in leukemia, and to identifying novel therapeutic targets. Dr. Bernt received her MD from the Humboldt University in Berlin, Germany. After residency at the Texas Children's Hospital and Fellowship at Boston Children's Hospital / Dana Farber Cancer Institute, Dr. Bernt went on to faculty positions at the University of Colorado, and in 2017 the Children's Hospital of Philadelphia / University of Pennsylvania. Dr. Bernt is a member of the NCI designated Abramson Cancer Center, the American Society of Hematology (ASH), the American Association of Cancer Research AACR), and the Children's Oncology Group (COG). https://www.theberntlab-chop.org/outside-the-lab daily 0.75 2025-10-08 https://www.theberntlab-chop.org/outside-the-lab/philadelphia-flyers-game-2025 monthly 0.5 2025-03-07 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/bcf59e17-2dbf-43e6-b393-3a4208c467a6/Picture+in+front+of+rink.JPG https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/60f0fd70-774f-428b-b34c-4dd6d24dbe74/Group+Selfie.jpg https://www.theberntlab-chop.org/outside-the-lab/winter-holiday-party-2024 monthly 0.5 2025-01-30 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/2c4f683c-0676-42ce-b489-b42e26d463dc/Soniya+Daniela+Casey+.jpg Outside The Lab - Winter Holiday Party 2024 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/ded0e6fb-2358-4d35-968b-f26ea3eac0fb/Daniela+Casey+Han.jpg Outside The Lab - Winter Holiday Party 2024 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/ac035270-0543-48ab-b3ed-3712a46af028/Han.jpg Outside The Lab - Winter Holiday Party 2024 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/3c255170-eef1-41f4-a627-d3e8f61c597e/Fatemeh+and+Soniya.jpg Outside The Lab - Winter Holiday Party 2024 https://www.theberntlab-chop.org/outside-the-lab/halloween-2014 monthly 0.5 2024-11-01 https://www.theberntlab-chop.org/outside-the-lab/halloween-2024-dress-up-as-your-alternate-career monthly 0.5 2024-11-01 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/8a35a51c-d72d-466d-8b44-ebb5fb53da28/Group+Photo+Theme+Alternate+Careers.jpg https://www.theberntlab-chop.org/outside-the-lab/new-portfolio-item-1 monthly 0.5 2024-11-01 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/afb09469-e28d-4043-a2d7-c223f145a4bc/IMG_2819.jpeg Outside The Lab - Flyers Game 2023 https://www.theberntlab-chop.org/outside-the-lab/new-portfolio-item monthly 0.5 2024-11-01 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/39b4ebbb-4745-44ae-be48-9833fb39bff1/picture5.jpeg Outside The Lab - Six Flags 2023 https://www.theberntlab-chop.org/outside-the-lab/project-four-ascsp monthly 0.5 2021-02-24 https://www.theberntlab-chop.org/outside-the-lab/halloween-2018 monthly 0.5 2021-02-24 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1614190573682-J2HB7RTXZWM7JIB0O03Y/20191031_210148.jpg Outside The Lab - Halloween 2019 https://www.theberntlab-chop.org/outside-the-lab/annual-phillies-game monthly 0.5 2021-02-25 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1614263296169-FL9JBWGKWR398GIPXQRD/IMG_3495.jpg Outside The Lab - Annual Phillies Game https://www.theberntlab-chop.org/outside-the-lab/halloween-2021 monthly 0.5 2021-11-01 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1635786022917-65HQS50RJH6M2BQ7DLD9/Img4+from+Jade.jpg Outside The Lab - Halloween 2021 From left to right: Joan Jett, Mozart, Justin Bieber, Kurt Cobain, Amy Winehouse, Prince, Freddie Mercury, ABBA, Slash, and Elton John! https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1635786212012-Z1FU6DC15JU2LWSBY40X/20211031_193055.jpg Outside The Lab - Halloween 2021 - Kathrin Bernt as Amy Winehouse! https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1635786328036-1YU2J1BIIV4SE5UUB5WH/20211031_192825.jpg Outside The Lab - Halloween 2021 - Simone Riedel as Slash! https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/3113ac96-9fbc-44d7-8315-8508cb6b6f07/IMG_20211030_175041_089.JPG Outside The Lab - Halloween 2021 - Fatemeh Alikarami as Joan Jett! https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1635786427316-T2YLMR3O36MUAKXQ139I/20211031_192946.jpg Outside The Lab - Halloween 2021 - Kevin Nestler as Justin Bieber! https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1635786478360-36ZK83ETDO1RCO2T63KW/20211031_192726.jpg Outside The Lab - Halloween 2021 - Leila Mahdavi as ABBA! https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1635786521666-FO4KC6BYTORFOIQA5LY9/20211031_192807.jpg Outside The Lab - Halloween 2021 - Declan Barrett as Elton John! https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1635786571056-WG0S05EXFZ1QK66F30WI/20211031_192639.jpg Outside The Lab - Halloween 2021 - Jade Dodge as Prince! https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1635786603670-GLDYBQWE6AW2C1I6FMES/20211031_192847.jpg Outside The Lab - Halloween 2021 - Brandon Mamou as Kurt Cobain! https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1635786641536-NS1UAV6P42LZB00E0UPA/20211031_192708.jpg Outside The Lab - Halloween 2021 - Caroline Buchner as Freddie Mercury! https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1635786706894-0UJ9545V1QXD424CEA44/20211031_192916.jpg Outside The Lab - Halloween 2021 - Hailey Faust as Mozart! https://www.theberntlab-chop.org/outside-the-lab/project-three-6ga25 monthly 0.5 2021-02-24 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1614189515583-FO83LL4O6LCLS1F5VBPU/IMG_6584+%281%29.JPG Outside The Lab - Halloween 2018 https://www.theberntlab-chop.org/outside-the-lab/project-two-s9e52 monthly 0.5 2021-02-24 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1614188638284-CTG3CTO819OCCGITMR32/thumbnail_Image.jpg Outside The Lab - Halloween 2020 Simone as Grindelwald from "Fantastic Beasts: The Crimes of Grindelwald" https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1614188686827-W3EERT7WXLFFNYIEUP8M/thumbnail_PXL_20201031_222109592.PORTRAIT-01.COVER.jpg Outside The Lab - Halloween 2020 Kevin as Captain Jack Sparrow from Pirates of the Caribbean https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1614188691702-DZQO0PGWPHFIMWGJTSEG/thumbnail_PXL_20201031_222601657.PORTRAIT-01.COVER.jpg Outside The Lab - Halloween 2020 Kathrin as William Blake from "Dead Man" https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1614188701606-ZCMH1FN3CQ4OIUL2KTIC/thumbnail_PXL_20201031_222519261.PORTRAIT-01.COVER.jpg Outside The Lab - Halloween 2020 Fatemeh as Sweeney Todd https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1614189348566-7AG2JV5BE4YERZTYIGTL/thumbnail_PXL_20201031_222240104.PORTRAIT-01.COVER+%281%29.jpg Outside The Lab - Halloween 2020 Ali as Willy Wonka https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1614189368449-07B4MYF5N3PMNH99O8F2/Halloween+2020+%281%29.jpg Outside The Lab - Halloween 2020 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1614189358624-8U7GORMHALM6LSZ9A5W7/thumbnail_937B320D-A3C2-4ABA-A350-E420D20A28D8.jpg Outside The Lab - Halloween 2020 https://www.theberntlab-chop.org/outside-the-lab/beekeeping-2025 monthly 0.5 2025-10-08 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1ea44176-9fe0-4e1c-8f7c-20d0df7cc8c6/IMG_6411.jpg Outside The Lab - Beekeeping 2025 Finding the queen bee https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/3805a881-dbe3-48a6-b817-9adfb485e51d/IMG_6418.jpg Outside The Lab - Beekeeping 2025 Monitoring the different comb layers https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/135b19c8-4cbb-4ec5-99ed-96081c107065/IMG_6392.jpg Outside The Lab - Beekeeping 2025 Haley holding comb https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/c1be7489-adb4-415f-85ea-ded8126d16fa/IMG_6373.jpg Outside The Lab - Beekeeping 2025 Looking for the queen https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/8816b79a-0492-4fef-8a09-13df807db7c7/IMG_6370.jpg Outside The Lab - Beekeeping 2025 Drone pods https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/2859adf2-6bab-4267-9ba0-5a9328e97206/IMG_6352.jpg Outside The Lab - Beekeeping 2025 Lab learning about hive dynamics https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/febd3730-dff4-46c9-94c1-e20c92f9e9a9/IMG_6372.jpg Outside The Lab - Beekeeping 2025 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/bf6a2955-3f95-46f4-821f-9c9aed3a4c7b/IMG_6366.jpg Outside The Lab - Beekeeping 2025 capped honey https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/bc03b465-0fc6-4265-adbb-65aa0676f4e1/IMG_6367.jpg Outside The Lab - Beekeeping 2025 https://www.theberntlab-chop.org/outside-the-lab/project-one-ldtmt monthly 0.5 2021-02-24 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1614203082978-0IJQC4N9P12EVOZWA0O8/Horseback+riding+1.7.2021.jpg Outside The Lab - Horseback Riding 1/8/21 https://www.theberntlab-chop.org/outside-the-lab/halloween-2023 monthly 0.5 2024-01-08 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/7f407677-e694-494e-901f-c5795c893c59/thumbnail_IMG_7991.jpg Outside The Lab - Halloween 2023 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/ade334eb-c0c1-4305-a6ac-8edcd45eefaf/thumbnail_IMG_7989.jpg Outside The Lab - Halloween 2023 https://www.theberntlab-chop.org/outside-the-lab/holiday-party-2023 monthly 0.5 2024-11-01 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/81e79c29-a0d5-4218-a6ff-196f3e981367/a.jpg Outside The Lab - Winter Holiday Party 2023 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/a1d30c11-83e0-41c8-9b0e-0550eac574bd/b.jpg Outside The Lab - Winter Holiday Party 2023 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/9e18b395-c7bd-470c-80fd-33680952c73b/c.jpg Outside The Lab - Winter Holiday Party 2023 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/b6132402-ee5c-4292-82f7-0139ef50bc53/d.jpg Outside The Lab - Winter Holiday Party 2023 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/6ae45ae7-b0dc-435c-9356-6608c68128f2/e.jpg Outside The Lab - Winter Holiday Party 2023 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/7acd0596-62d0-40b8-9805-3d3d967a0dc0/f.jpg Outside The Lab - Winter Holiday Party 2023 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/19550b3f-111b-4e0b-921f-c49f7f085298/g.jpg Outside The Lab - Winter Holiday Party 2023 https://www.theberntlab-chop.org/past-lab-members-1 daily 0.75 2025-10-08 https://www.theberntlab-chop.org/past-lab-members-1/haley-goodrow-ba monthly 0.5 2025-10-08 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1721074570505-K71FMVZCV4TQ5JFFSYW0/Haley+w+cardamom.jpg https://www.theberntlab-chop.org/past-lab-members-1/soniya-athavale monthly 0.5 2025-10-08 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/c8cf50f4-394b-4e12-8c3a-e2ffb6b16f13/soniya.png https://www.theberntlab-chop.org/past-lab-members-1/daniel-winters monthly 0.5 2025-10-08 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/d04cbe22-cd29-4ba7-91e2-d72d4582216f/Screenshot_20240116-152940.png https://www.theberntlab-chop.org/past-lab-members-1/kevin-nestler monthly 0.5 2023-10-13 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/eb0a4927-4211-46dc-9008-c3212adb1c78/Capture.PNG https://www.theberntlab-chop.org/past-lab-members-1/jessica-haladyna monthly 0.5 2021-03-01 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1614205189218-AL9OA83S9J9VU36BU2NP/juuarvaazgeu2wvfpm7l.jpg Past Lab Members - Jessica Haladyna, MD - Jessica Haladyna Jess is a former member of the Bernt Lab who has gone on to do spectacular things. After doing incredible research into epigenetic modifiers in normal and malignant hematopoiesis, she went on to study at Georgetown University School of Medicine. She is now a pediatric hematology/oncology fellow at the Children's Hospital of Los Angeles. https://www.theberntlab-chop.org/past-lab-members-1/gina-south monthly 0.5 2021-03-01 https://www.theberntlab-chop.org/past-lab-members-1/kelly-faulk monthly 0.5 2021-03-01 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/a0407fb9-662f-4b56-b544-566564d204ff/Picture3.jpg Past Lab Members - Kelly Faulk, MD - Kelly Falk Kelly trained with the Bernt Lab during her fellowship at Colorado Children’s Hospital. She is now an Assistant Professor at Colorado Children’s Hospital and a COG Phase 1 Investigator. https://www.theberntlab-chop.org/past-lab-members-1/taylor-pasteur monthly 0.5 2021-03-01 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1614205100612-XM3ENN3J365B20NR9MUB/TP.JPG Past Lab Members - Taylor Pasteur, RN - Taylor Pasteur Taylor began working in the Bernt Lab after graduating from Wellesley College. She assisted on a number of projects, including the initial research exploring the epigenetic regulation of protein translation in KMT2A-rearranged AML, and maintained the lab’s function through its move from Denver to Philadelphia. Taylor went on to complete the Fact-1 Nursing program at Thomas Jefferson University and become an RN. https://www.theberntlab-chop.org/past-lab-members-1/molly-kingsley monthly 0.5 2021-03-01 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1614205045966-1CASA8A865Z3A0ZKMP6T/MK.JPG Past Lab Members - Molly Kingsley, PhD - Molly Kingsley Molly was a grad student in the Bernt Lab who completed her PhD in 2020. Her scientific interests revolved around how specific patterns of H3K79 methylation influence genetic interaction of oncogenes in AML. Molly completed her Postdoctoral Fellowship at Tufts University and is now working in Biotech. https://www.theberntlab-chop.org/past-lab-members-1/clara-libbrecht monthly 0.5 2021-06-14 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1614204997575-CWVJ1VQOX9MT5EPLRLYO/CL.jpg Past Lab Members - Clara Libbrecht, MD, PhD - Clara Libbrecht Clara was a graduate student in the Bernt Lab who finished her PhD in 2020. Her primary focus was to explore the role of Menin in the long term maintenance of meningioma-1 driven leukemia. She previously completed her M.D. at L’Université de Lyon in France. Clara also completed her residency at Boston Children’s Hospital and is now a pediatric hematologist/oncologist at Seattle Children’s Hospital. https://www.theberntlab-chop.org/past-lab-members-1/ali-lenard monthly 0.5 2021-07-06 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/1625588497686-Y6KTV09ACZW8EL03M7F2/IMG_4904.jpg Past Lab Members - Ali Lenard, B.S. - Ali Lenard Originally from Wayne, PA, Ali graduated from Bucknell University in 2018 with a B.S. in Biology & a minor in Anthropology. She started in the Bernt Lab shortly after and dove into a research project exploring the epigenetic regulation of protein translation in a specific subset of leukemia. After this paper’s publication, Ali moved onto a collaboration with Syndax Pharmaceuticals exploring the role of menin inhibition in rare & aggressive rearranged leukemias. Apart from this project, Ali also maintained the mouse colony and bred our rare genetic mouse models. After the Bernt Lab, Ali went on to earn her nursing degree and work at the NICU at CHOP. Ali enjoys skiing with her family & friends, baking, as well as traveling (in a non-pandemic world). Publications: Lenard A, Xie HM, Pastuer T, Shank T, Libbrecht C, Kingsley M, Riedel SS, Yuan ZF, Zhu N, Neff T, Bernt KM. Epigenetic regulation of protein translation in KMT2A-rearranged AML. Exp Hematol. 2020 May;85:57-69. doi: 10.1016/j.exphem.2020.04.007. Epub 2020 May 11. PMID: 32437908. https://www.theberntlab-chop.org/past-lab-members-1/leila-mahdavi-bs monthly 0.5 2025-10-08 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/2159b0ce-db8a-4e82-8f6a-b240ffb8fe6d/Picture1.jpg https://www.theberntlab-chop.org/past-lab-members-1/declan-barrett-bs monthly 0.5 2025-10-08 https://images.squarespace-cdn.com/content/v1/603655f350f9d152a0d9081c/9965093d-8799-4974-84fc-45d8743efefd/Picture2.jpg